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SEMA4D/CD100, a novel target for immuneoncology Cancer Biology
Multiple myeloma (MM) is characterized by bone destruction due to increased bone resorption and decreased bone formation. Semaphorin 4D (CD100, Sema4D) is expressed by osteoclasts, binds to its.
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SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Cholangitis, Primary Sclerosing and Diffuse Glomerulonephritis.Among its related pathways are Semaphorin interactions and Nervous system development.Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transmembrane signaling receptor activity.
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Frontiers The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis
Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinic.
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Sema4 Launches New Genomic Testing and Digital Tools for Use in Oncology Business Wire
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Semaphorin 4D (Sema4D) is a classic member of the semaphorin family involved in axonal guidance processes. The key effects of Sema4D in neurons are mediated by high affinity plexin receptors and are associated with cytoskeleton rearrangement, leading to growth cone collapse or regulation of cell migration. Along with this, the semaphorin is.
IJMS Free FullText DualFunction Semaphorin 4D Released by Platelets Suppression of
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SIGNAL is a multicenter, randomized, double-blind, placebo-controlled phase 2 study (no. NCT02481674) established to evaluate pepinemab, a semaphorin 4D (SEMA4D)-blocking antibody, for treatment.
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