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Orlistat, a weight-loss agent with a novel mechanism of action, recently was approved by the Food and Drug Administration for the treatment of obesity. It inhibits gastric and pancreatic lipases in the lumen of the gastrointestinal tract to decrease systemic absorption of dietary fat. In several trials lasting up to 2 years, orlistat was more.
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Orlistat side-effects. The common side-effects of orlistat are caused by the fat which is passed out with your stools (faeces). You may have fatty smelly stools, urgency to get to the toilet, oily spotting on your underwear, and excess wind. These side-effects are less likely if you eat a low-fat diet.
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A method to effectively treat the adverse events of ingested orlistat, and to maintain the effectiveness of ingested orlistat, the method comprising the steps of: ingesting a compound of orlistat to irreversibly bind with lipase enzymes of the gastrointestinal tract; ingesting a compound of simethicone to cause undigested fats to remain in an emulsified state in the bowel; and ingesting an.
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Konsumsi orlistat dengan makanan yang tinggi lemak dapat meningkatkan risiko terjadinya efek samping. Orlistat dapat menghambat penyerapan vitamin yang larut dalam lemak, yaitu vitamin A, D, E, K. Jika Anda ingin mengonsumsi suplemen untuk memenuhi kebutuhan vitamin ini, jangan mengonsumsinya bersamaan dengan orlistat.
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WO2008149321A3 PCT/IB2008/052242 IB2008052242W WO2008149321A3 WO 2008149321 A3 WO2008149321 A3 WO 2008149321A3 IB 2008052242 W IB2008052242 W IB 2008052242W WO 2008149321 A3 WO2008149321 A3 WO 2008149321A3 Authority WO WIPO (PCT) Prior art keywords orlistat preparation pfa provides present Prior art date 2007-06-06 Application number PCT/IB2008/052242
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Orlistat is a medicine that can help you to lose weight if you are obese or overweight. It works by interfering with the way fat is digested and absorbed by your body. It prevents the action of enzymes found in the digestive juices of your stomach and small intestine. These enzymes normally break down the fat which you consume in your diet.
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The preferred amounts for orlistat are about 10 to about 360 mg, preferably about 30 to about 120 mg and most preferably about 40 to about 80 mg. The pharmaceutical compositions may contain about 0.1 to about 20 g bile acid sequestrant, preferably about 0.5 to about 10 g, and most preferably about 1 to about 5 g.
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US 8,680,298 B2 3 In general, amino orlistat may be obtained by deprotecting a protected amino orlistat. The Pivaloyl Formic Anhydride may be obtained by react
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Description. The present invention relates to improved processes for the preparation of orlistat, which is N-formyl-L-leucine derivative, in high purity. Orlistat, a tetrahydrolipstatin, is a useful pancreatic lipase-inhibiting agent and can be used for the prevention and treatment of obesity and hyperlipaemia.
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Deskripsi. ORLISTAT 120 MG merupakan obat yang mengandung orlistat. Orlistat digunakan bersama makanan rendah kalori, sebagai terapi tambahan pada pasien obesitas dengan Index Massa Tubuh (Body Mass Index/BMI) 30 kg/m2 dan diatasnya atau pasien yang berkelebihan berat badan dengan BMI 27 kg/m2 dan diatasnya yang memiliki faktor risiko terkait.
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Orlistat (marketed as Alli and Xenical) Information. Xenical (orlistat 120mg) was approved as a prescription product by FDA in 1999 for obesity management in conjunction with a reduced caloric.
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Orlistat is a medication used in the management of obesity. Orlistat acts by reversibly inhibiting gastric and pancreatic lipases. The inactivation of lipases prevents the hydrolysis of triglycerides, and thus free fatty acids are not absorbed. The maximum benefit of orlistat occurs when used in conjunction with diet and exercise. This activity reviews the indications, actions, and.
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Abstract. A stable pharmaceutical composition comprising dispersion blend comprising 20 to 60% by weight of orlistat and 40% to 80% by weight of water soluble polymer carrier selected from hydroxypropyl methyl cellulose, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose or hydroxypropyl methylcellulose and the like.
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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity.Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.. Orlistat is the saturated derivative of lipstatin, a.